Hutchinson Technology is trimming about 10 percent of its workforce, and will cut 165 positions in Eau Claire.
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Company leaders say the layoffs will affect workers from all shifts and departments, including manufacturing and support positions.
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In a statement released today, HTI leaders say: "This is a very difficult decision, but necessary in order for HTI to be a profitable and growing company."
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The company is reporting an estimated loss of about $6 million, or 23 cents per share, in the first eight weeks of the fiscal third quarter.
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Before the layoffs, about 5,300 employees worked for the company's four U.S. locations.
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This will cut HTI's workforce by 10 percent nationally and in Eau Claire.
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The announcement comes just two months after 3M announced the closing of its Eau Claire plant.