Derrek Lee and Cliff Floyd each had four hits as the Chicago Cubs.
Floyd hit a two-run double in Chicago's five-run fourth, while Lee hit a solo homer in the fifth. It was Lee's first home run since last September eleventh.
Ted Lilly improved to 2-and-2 giving up six hits and one earned run over seven innings.
Tony Graffanino had two hits and an R-B-I for Milwaukee.
It was just 44 degrees at Wrigley Field when the game began after a 71-minute rain delay.