Cuddyer hit a three-run homer, went 2-for-3 and scored two runs. Ford hit a two-run drive and a run-scoring double.
Minnesota has won the first two games of the weekend series between the A-L Central rivals. Detroit has lost four of its last five.
Curtis Granderson, Marcus Thames, and Ivan Rodriguez homered for the Tigers.
Kevin Slowey outpitched fellow rookie Andrew Miller to get the win. Slowey gave up four runs and nine hits in six innings, struck out two and walked one.