Justin Morneau's RBI single in the bottom of the 10th gave the Minnesota Twins a 2-1 victory over Cleveland.
Morneau, who struck out with a runner on second in the eighth inning, is 9-for-15 with 12 RBIs with runners in scoring position.
Rafael Perez suffered the loss after an impressive start by Paul Byrd. The defending AL Central champions have now lost 12-of-16 after a 2-and-0 start.
Brendan Harris also homered for Minnesota.
Matt Guerrier pitched an inning of relief for the win. He's 1-and-1.